منابع مشابه
Adenylate Cyclase in Islets of Langerhans ISOLATION OF ISLETS AND REGULATIOK OF ADENYLATE CYCLASE ACTIVITY BY- VAR.IOUS
An improved method for the isolation of rat pancreatic islets possessing adenylate cyclase responsive to various hormones and agents is described. The key step in this method, which yielded up to 500 islets per pancreas, involved pretreatment of rats with pilocarpine. This allowed depletion of zymogens from the exocrine pancreatic tissue and thus minimized the destruction of islet membranal str...
متن کاملCalmodulin activation of adenylate cyclase in pancreatic islets.
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin rele...
متن کاملE VALUATION OF ADENYLATE CYCLASE ACTIVITY IN MITRAL VALVE PROLAPSE
The term mitral valve prolapse (MVP) is used for a particular subset of patients with hyperadrenergic dysautonomia. It occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. The adenylate cyclase activity in MVP dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 norma...
متن کاملRapid Publications Stimulation of Adenylate Cyclase by Ca and Calmodulin in Rat Islets of Langerhans Explanation for the Glucose-induced Increase in Cyclic AMP Levels
The effect of Ca and calmodulin has been studied on adenylate cyclase activity in homogenates of rat islets of Langerhans. EGTA had a stimulatory effect on the enzyme in accord with the known inhibitory effect of Ca. In contrast, the addition of Ca together with calmodulin is stimulatory and demonstrates the existence of a Ca-dependent adenylate cyclase in islets of Langerhans. It is suggested ...
متن کاملe valuation of adenylate cyclase activity in mitral valve prolapse
the term mitral valve prolapse (mvp) is used for a particular subset of patients with hyperadrenergic dysautonomia. it occurs when part of a leaflet or both leaflets of the mitral valve extend above the plane of the atrioventricular junction during ventricular systole. the adenylate cyclase activity in mvp dys-autonomia was studied by extraction of enzyme from the erythrocytes from 62 normal su...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)44063-5